Effects of Progestin

Effects of progestin is different than natural progesterone. Synthetic hormones are the primary hormones that are prescribed for hormone replacement therapy (HRT). Synthetic hormones are derived from synthetic sources and don't function the same in the human body as natural progesterone. 

What is Progestin?

Progestin is defined as any compound able to sustain the human secretory endometrium. 

This definition refers to keeping the lining of the uterus healthy and rich in blood, preparing for pregnancy and also supporting the developing embryo. When a woman comes to the end of her monthly cycle and no pregnancy has occurred, the levels of her reproductive hormones drop dramatically and in response the lining of the uterus is shed in menstruation. 

Most medical literature has confused many people by classifying progestins as natural progesterone. There is only one progesterone, the specific molecule made by the adrenal glands or by the ovary as a consequence of ovulation. A more accurate definition of progestin is any compound other than natural progesterone able to sustain the human endometrium. 


Differences between progesterone and progestins

It's important to understand progesterone isn't the same as progestins, and there are side effects of progestin. 

Fertility doctors always use progesterone, not progestins. 

Progestins are associated with birth defects, while progesterone is essential for a viable and healthy pregnancy. 

Synthetic progestins don't show up in blood and saliva tests of progesterone levels. In other words, progestins don't raise the level of progesterone in the body. 

Pregnant women are making 300mg of progesterone daily in the last trimester. These women don't have higher rates of breast cancer as women who use progestins do. 

Natural progesterone doesn't cause the side effects Provera does. Provera is the most commonly used synthetic progestin for HRT. 


Provera and effects of progestins

Provera (Medroxyprogesterone Acetate) has many potential side effects. 

If taking this drug during the first four months of pregnancy, there is an increased risk of minor birth defects. 

Discontinue using this drug if there is sudden partial or complete loss of vision. 

In the milk of mothers receiving this drug, detectable amounts of progestin have been identified. 

Progestogens may cause some degree of fluid retention. Epilepsy, migraine, asthma, and cardiac or renal dysfunction are conditions that might be influenced by this factor. 

Provera effects of progestin may cause breakthrough bleeding or menstrual irregularities. Also, this drug could contribute to depression. 

Effects of Progestin

Adverse Reactions to Provera

Some adverse reactions and effects of progestin include... 

  • mental depression, pyrexia, nausea, insomnia, or somnolence


  • fatigue, backache, itching, dizziness, nervousness, loss of scalp hair


  • acne, alopecia, and hirsutism


  • breast tenderness and galactorrhea


  • sensitivity reactions such as urticaria, prutitus, edema, or rash


  • cholestatic jaundice


  • anaphylactoid reactions and anaphylaxis (severe acute allergic reactions)


  • Thrombophlebitis and pulmonary embolism


  • breakthrough bleeding, spotting, amenorrhea, or changes in menses


  • cervical erosions and changes in cervical secretions.


  • edema, weight changes

Natural Progesterone and Synthetic Progestins

Most progestins are synthesized from progesterone or from another synthetic hormone called nortestosteron, and none of them are found in nature. 

Since progesterone is a natural hormone, the body is normally able to produce it, use it, and eliminate it when needed. Synthetic progestins aren't produced well by the body. the activity of progestins is prolonged and it creates reactions in the body that aren't consistent with natural progesterone. 

Progestins bind to the same cell receptors as progesterone does, however, progestins carry a different message due to the small alterations. Even though the differences are small, these differences in chemical structure no doubt explain the alarming list of warnings, contraindications, precautions, and adverse reactions to progestins, all of which are uncharacteristic of natural progesterone. 


› Effects of Progestin

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