Dog Medication, Prescription Dog Drugs

Dog Medication and information on prescription drugs for dogs. 

Potassium Bromide

Potassium Bromide decreases seizure action by working to depress excitability and neuronal activity by acting at the cellular level. Potassium bromide is usually best taken orally and is principally excreted by the kidneys. 

Potassium Bromide dog medication is an antiepileptic drug (AED) used in dogs to control seizures. Potassium Bromide is commonly used in combination with  Phenobarbital. 

Because it may take as long as 4 months to reach a steady state concentration of bromide in the brain, phenobarbital is rarely considered as a first line drug. 

Dogs that are suffering from hepatotoxicity due to Phenobarbital may be treated with Potassium Bromide alone because of its renal excretion. 

Because of the relatively high incidence of side effects, cats are rarely treated with Potassium Bromide dog medication. 

Client commitment and compliance are essential for the management of the animals with seizure disorders. Because both Potassium Bromide and Phenobarbital can be sedating. Therefore, clients need to understand that their pets may have a less active life style. The client will need to administer medication at prescribed regular intervals, and the animal will need regular blood work to monitor serum drug levels. 

Side effects include...

  • transient sedation

  • anorexia

  • lethargy

  • polyuria
    A condition characterized by the passage of large volumes of urine.

  • vomiting

  • polydipsia
    A medical symptom in which the patient ingests abnormally large amounts of fluids by mouth.

  • constipation

  • pancreatitis

Some Potassium Bromide precautions... 

Chloride ion levels affect Bromide levels because they compete for uptake across the cellular membrane. A low salt diet or sodium restriction can cause bromide toxicity. On the other hand, increased sodium diet will decrease Bromide levels creating a higher risk for dog to seizure. 

The reproductive safety of Bromide use in dogs has not been established.

Older animals may have a higher incidence of adverse side effects. 

The excretion of Potassium Bromide will be possibly increased by Drug Interactions Diuretics such as furosemide. 

Other drugs used to sedate the central nervous system could cause additional sedation when used in combination with Potassium Bromide. 

Overdose Bromism or toxicity due to chronic overdose is displayed as...

  • muscle pain

  • profound sedation

  • CNS signs

  • stupor

  • ataxia
    Ataxia means absence of order. Parts of the nervous system that normally control co-ordination are affected.

  • tremors

Acute overdose occurs less frequently than chronic overdose but with similiar symptoms such as profound sedation, ataxia and other CNS signs. Treatment could include diuretic, GI emptying, and use of IV fluids. 

Dog Medication

Dog Medication, Phenobarbital

Medication may be necessary for dogs that have frequent seizures. For dogs, phenobarbital is probably the first choice for suppressing seizure activity. It can be effective, safe if used responsibly, and is also one of the least expensive dog medications in all of veterinary practice. Periodic blood tests are usually recommended because phenobarbital treatment generally lasts the entire lifespan of the dog. 

Phenobarbital dog medication is most often used to suppress epileptic seizures, but it can also be used against seizures due to brain tumors, poisonings, or infection as well. 

Phenobarbital is absorbed well into the body when given orally and it’s peak activity occurs 4-8 hours after the pill is given. 

Some side effects... 

Excessive thirst, appetite, and urination are common side effects of phenobarbital. If these symptoms occur, they do not generally go away and if they are severe, medication may to be changed. 

Depression or sedation when starting phenobarbital treatment are other possible side effects. 

Chronic exposure to phenobarbital can lead to scarring in the liver and liver failure that can be irreversible. 

For these reasons, phenobarbital blood levels are periodically checked to determine if it's necessary to adjust the dose. 

In patients with poor liver function or liver failure, phenobarbital may not be the best choice in seizure control. 

Phenobarbital interferes with thyroid function testing as well as with adrenal function testing. It's very difficult to monitor hypothyroidism or Cushing’s disease in patients taking phenobarbital because test results are difficult to interpret. 


Piroxicam is a non-steroidal anti-inflammatoy drug (NSAID) that also has anti-tumor properties. It is most often used in pets for the treatment of certain types of cancers, especially bladder cancer. 

While your pet is given piroxicam dog medication treatment, contact your veterinarian if your pet experiences...

  • loss of appetite

  • depression

  • constipation

  • diarrhea

  • vomiting

  • jaundice (e.g., yellowing of the gums, skin, or whites of the eyes)

  • bloody or black stools

  • an increase in drinking and/or urination

  • lethargy

  • incoordination

  • seizures

  • shedding

  • behavior changes

  • hot spots

Do not give Piroxicam with other NSAIDs medications. There is a greatly increased risk of stomach ulcers if used with these medications. 

The most common side effects of NSAIDs, including piroxicam, are stomach bleeding and ulcers. 

Signs of stomach bleeding and ulcers may include loss of appetite, diarrhea, vomiting, dark or bloody stools, tarry stools, or constipation. 

Side effects involving the kidney include increased thirst and increased urination. 

Side effects involving the liver include jaundice (yellowing of the gums, skin, or eyes). 

The safety of the drug has not been determined in breeding, pregnant, or lactating animals (female animals nursing their young). 

Dog Medication, Phenoxybenzamine

Phenoxybenzamine is in the class of drugs known as alpha-adrenergic blocking agents. These drugs block or reverse the effects of alpha-receptor stimulation. 

Phenoxybenzamine dog medication blocks the effects of alpha-adrenergic receptors, resulting in dilation of the blood vessels. This drug also reduces the tone of smooth muscle in organs such as the bladder. 

Phenoxybenzamine is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. 

This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug. 

Dog Medication, Diethylstilbestrol

Diethylstilbestrol (DES) is a synthetic estrogen. Estrogen is one of the primary ovarian hormones and the pharmacologic actions of DES mimic those of estrogen. These include development and maintenance of female sexual organs and secondary sex characteristics.

DES dog medication is primarily used to treat urinary incontinence in spayed females. 

Estrogens increase urethral tone and help to prevent leaking or dribbling of urine. DES is usually effective for this purpose and the risk of side effects is relatively low due to the small dose. DES may be used with the alpha-agonist phenylpropanolamine. These drugs behave in a synergistic fashion. 

DES has been used for the prevention of pregnancy due to accidental breeding or mismating in dogs and cats. It is not generally recommended for this purpose, as it is not very effective. DES is used in the management or treatment of prostatic hypertrophy. 

The most serious side effect of estrogen therapy is bone marrow suppression and toxicity that may progress to a fatal aplastic anemia. 

Side effects are more common in older animals. Because of the potential toxic side effects of estrogen use, it is always important to use the lowest effective dose for the shortest period of time. 

Other side effects include signs of estrus, lethargy, diarrhea, vomiting, vaginal discharge, pyometra, polydypsia, polyuria, and feminization of male dogs. 

Some precautions... 

DES dog medication and other estrogens should not be used during pregnancy as it has been shown to cause fetal malformations. 

Drug Interactions Rifampin, phenobarbital, and phenylbutazone may decrease the activity of DES due to microsomal enzyme induction. 

DES and other estrogens may enhance corticosteroid activity. The corticosteroid dose may need to be adjusted. 

DES dog medication and other estrogens may decrease the activity of anticoagulants. 

Overdose in humans resulted in nausea, vomiting and bleeding. 

› Dog Medication

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